[Cutaneous signs and symptoms of X-linked chondrodysplasia punctata in man and mouse].

X-linked dominant chondrodysplasia punctata is a human gene defect characterized by stippled epiphyses, cataracts and cutaneous lesions distributed in a linear and blotchy pattern. The skin lesions include congenital ichthyosiform erythroderma, systematized atrophoderma mainly involving the hair follicles, and circumscribed alopecia. Similar cutaneous anomalies are described in the murine X-linked mutant bare-patches. Moreover, we found similar skeletal and ocular anomalies in this mouse, supporting the assumption that the underlying gene defects are homologous in man and mouse.