Journal of autism and developmental disorders · 2021
Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children.
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Horinouchi Tomoko, Maeyama Kaori, Nagai Masashi, Mizobuchi Masami, Takagi Yasuko, Okada Yuka, Kato Takeshi, Nishimura Mio, Kawasaki Yoko, Yoshioka Mieko, Takada Satoshi, Matsumoto Hisayuki, Nakamachi Yuji, Saegusa Jun, Fukushima Sachiyo, Fujioka Kazumichi, Tomioka Kazumi, Nagase Hiroaki, Nozu Kandai, Iijima Kazumoto, Nishimura Noriyuki
Аннотация
Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G > A), and UGT1A1*27 (c.686 C > A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.