International Consensus Criteria for Pediatric Sepsis and Septic Shock.
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Schlapbach Luregn J, Watson R Scott, Sorce Lauren R, Argent Andrew C, Menon Kusum, Hall Mark W, Akech Samuel, Albers David J, Alpern Elizabeth R, Balamuth Fran, Bembea Melania, Biban Paolo, Carrol Enitan D, Chiotos Kathleen, Chisti Mohammod Jobayer, DeWitt Peter E, Evans Idris, Flauzino de Oliveira Cláudio, Horvat Christopher M, Inwald David, Ishimine Paul, Jaramillo-Bustamante Juan Camilo, Levin Michael, Lodha Rakesh, Martin Blake, Nadel Simon, Nakagawa Satoshi, Peters Mark J, Randolph Adrienne G, Ranjit Suchitra, Rebull Margaret N, Russell Seth, Scott Halden F, de Souza Daniela Carla, Tissieres Pierre, Weiss Scott L, Wiens Matthew O, Wynn James L, Kissoon Niranjan, Zimmerman Jerry J, Sanchez-Pinto L Nelson, Bennett Tellen D, Society of Critical Care Medicine Pediatric Sepsis Definition Task Force
Аннотация
OBJECTIVE: To update and evaluate criteria for sepsis and septic shock in children.
EVIDENCE REVIEW: The Society of Critical Care Medicine (SCCM) convened a task force of 35 pediatric experts in critical care, emergency medicine, infectious diseases, general pediatrics, nursing, public health, and neonatology from 6 continents. Using evidence from an international survey, systematic review and meta-analysis, and a new organ dysfunction score developed based on more than 3 million electronic health record encounters from 10 sites on 4 continents, a modified Delphi consensus process was employed to develop criteria.
FINDINGS: Based on survey data, most pediatric clinicians used sepsis to refer to infection with life-threatening organ dysfunction, which differed from prior pediatric sepsis criteria that used systemic inflammatory response syndrome (SIRS) criteria, which have poor predictive properties, and included the redundant term, severe sepsis. The SCCM task force recommends that sepsis in children be identified by a Phoenix Sepsis Score of at least 2 points in children with suspected infection, which indicates potentially life-threatening dysfunction of the respiratory, cardiovascular, coagulation, and/or neurological systems. Children with a Phoenix Sepsis Score of at least 2 points had in-hospital mortality of 7.1% in higher-resource settings and 28.5% in lower-resource settings, more than 8 times that of children with suspected infection not meeting these criteria. Mortality was higher in children who had organ dysfunction in at least 1 of 4-respiratory, cardiovascular, coagulation, and/or neurological-organ systems that was not the primary site of infection. Septic shock was defined as children with sepsis who had cardiovascular dysfunction, indicated by at least 1 cardiovascular point in the Phoenix Sepsis Score, which included severe hypotension for age, blood lactate exceeding 5 mmol/L, or need for vasoactive medication. Children with septic shock had an in-hospital mortality rate of 10.8% and 33.5% in higher- and lower-resource settings, respectively.
CONCLUSIONS AND RELEVANCE: The Phoenix sepsis criteria for sepsis and septic shock in children were derived and validated by the international SCCM Pediatric Sepsis Definition Task Force using a large international database and survey, systematic review and meta-analysis, and modified Delphi consensus approach. A Phoenix Sepsis Score of at least 2 identified potentially life-threatening organ dysfunction in children younger than 18 years with infection, and its use has the potential to improve clinical care, epidemiological assessment, and research in pediatric sepsis and septic shock around the world.