Clinical toxicology (Philadelphia, Pa.) · 2025
Phosphine poisoning: a case series including one fatality following fumigation with aluminium phosphide.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Asan Hande, Satılmış Dilay, Koka Hanım Asya, Yolsal Emir Can, Keçeci Elif, Cevik Erdem
Аннотация
INTRODUCTION: Aluminium phosphide is a highly toxic fumigant pesticide that releases phosphine upon contact with moisture. Phosphine primarily targets the cardiovascular system and may result in multi-organ failure.
CASE SERIES: Four individuals from the same household were exposed when the apartment directly below their own was fumigated. After the index case was diagnosed with acute gastroenteritis and discharged, he found a housemate unconscious. On admission, she had a Glasgow Coma Scale of 4, her pulse rate was 43 beats/min, her temperature was 34.3 °C, and her blood pressure was 85/60 mmHg. Her pupils were fixed and dilated; she suffered cardiac arrest and died 8 h after admission. Complaints of nausea and vomiting in two others led to the consideration of a potential toxic exposure.
DISCUSSION: Toxic exposure should be considered when multiple individuals from the same environment present with similar symptoms. This case series highlights the diagnostic challenge posed by phosphine inhalation as a result of aluminium phosphide use. Early symptoms may mimic benign conditions such as gastroenteritis. In fatal cases, rapid progression to shock, dysrhythmias, and multi-organ failure may occur.
CONCLUSION: Four individuals from the same household were exposed to phosphine generated from the use of aluminium phosphide; one died after developing severe cardiovascular collapse.
CASE SERIES: Four individuals from the same household were exposed when the apartment directly below their own was fumigated. After the index case was diagnosed with acute gastroenteritis and discharged, he found a housemate unconscious. On admission, she had a Glasgow Coma Scale of 4, her pulse rate was 43 beats/min, her temperature was 34.3 °C, and her blood pressure was 85/60 mmHg. Her pupils were fixed and dilated; she suffered cardiac arrest and died 8 h after admission. Complaints of nausea and vomiting in two others led to the consideration of a potential toxic exposure.
DISCUSSION: Toxic exposure should be considered when multiple individuals from the same environment present with similar symptoms. This case series highlights the diagnostic challenge posed by phosphine inhalation as a result of aluminium phosphide use. Early symptoms may mimic benign conditions such as gastroenteritis. In fatal cases, rapid progression to shock, dysrhythmias, and multi-organ failure may occur.
CONCLUSION: Four individuals from the same household were exposed to phosphine generated from the use of aluminium phosphide; one died after developing severe cardiovascular collapse.