Frontiers in cellular and infection microbiology · 2026
Bacterial pathogen spectrum and antimicrobial resistance in positive pus cultures from hospitalized patients at a maternal and child healthcare specialty hospital in Shenzhen, China, 2021-2025.
СтатьяНазвание и аннотация: Перевод в очереди
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Ding Tongyan, Liu Xiaochun, Liao Futing, Lin Shaoxiang, Liu Shuyan, Yang Shujuan, Zhou Xiaojie, Zhang Qiaoxin, Zhou Zhenwen
Аннотация
OBJECTIVE: Pus culture and antimicrobial susceptibility testing play an important role in pathogen identification and the adjustment of empirical therapy for localized suppurative infections. This study aimed to investigate the distribution of major bacterial pathogens isolated from pus cultures and their susceptibility profiles to commonly used antimicrobial agents among hospitalized patients at Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, in order to provide evidence for rational clinical antimicrobial use.
METHODS: We retrospectively collected pus culture records and aggregated antimicrobial susceptibility data from January 1, 2021 to December 31, 2025.
RESULTS: From 2021 to 2025, 586 non-duplicate bacterial isolates were recovered from positive pus cultures, of which 64.7% were Gram-negative and 35.3% were Gram-positive. The leading isolates were Escherichia coli (48.0%) and Staphylococcus aureus (22.5%), followed by Klebsiella pneumoniae subsp. pneumoniae (7.0%), Staphylococcus epidermidis (3.8%), Pseudomonas aeruginosa (2.4%), and Streptococcus agalactiae (1.4%). Positive cultures were mainly from the Departments of Pediatric Surgery, General Surgery, Gynecology, and Breast Surgery, with a bimodal age distribution peaking in young children and women of reproductive age; among Pediatric Surgery cases, males predominated, especially in the 0-3-year group. Extended-spectrum beta-lactamase production was detected in 28.1% of Escherichia coli and 20.0% of Klebsiella pneumoniae subsp. pneumoniae isolates. Escherichia coli showed high resistance to ampicillin, trimethoprim-sulfamethoxazole, and ciprofloxacin but remained highly susceptible to imipenem and amikacin. Klebsiella pneumoniae subsp. pneumoniae remained highly susceptible to amikacin, cefoxitin, and ertapenem despite resistance to several cephalosporins and ciprofloxacin. A subset of Staphylococcus aureus isolates was methicillin resistant, with frequent resistance to erythromycin and clindamycin, whereas vancomycin and linezolid retained good in vitro activity.
CONCLUSIONS: Empirical antimicrobial therapy for localized suppurative infections in this maternal and child healthcare specialty hospital should be guided by local pathogen distribution and antimicrobial susceptibility surveillance, with coverage for both Enterobacterales and staphylococci.
METHODS: We retrospectively collected pus culture records and aggregated antimicrobial susceptibility data from January 1, 2021 to December 31, 2025.
RESULTS: From 2021 to 2025, 586 non-duplicate bacterial isolates were recovered from positive pus cultures, of which 64.7% were Gram-negative and 35.3% were Gram-positive. The leading isolates were Escherichia coli (48.0%) and Staphylococcus aureus (22.5%), followed by Klebsiella pneumoniae subsp. pneumoniae (7.0%), Staphylococcus epidermidis (3.8%), Pseudomonas aeruginosa (2.4%), and Streptococcus agalactiae (1.4%). Positive cultures were mainly from the Departments of Pediatric Surgery, General Surgery, Gynecology, and Breast Surgery, with a bimodal age distribution peaking in young children and women of reproductive age; among Pediatric Surgery cases, males predominated, especially in the 0-3-year group. Extended-spectrum beta-lactamase production was detected in 28.1% of Escherichia coli and 20.0% of Klebsiella pneumoniae subsp. pneumoniae isolates. Escherichia coli showed high resistance to ampicillin, trimethoprim-sulfamethoxazole, and ciprofloxacin but remained highly susceptible to imipenem and amikacin. Klebsiella pneumoniae subsp. pneumoniae remained highly susceptible to amikacin, cefoxitin, and ertapenem despite resistance to several cephalosporins and ciprofloxacin. A subset of Staphylococcus aureus isolates was methicillin resistant, with frequent resistance to erythromycin and clindamycin, whereas vancomycin and linezolid retained good in vitro activity.
CONCLUSIONS: Empirical antimicrobial therapy for localized suppurative infections in this maternal and child healthcare specialty hospital should be guided by local pathogen distribution and antimicrobial susceptibility surveillance, with coverage for both Enterobacterales and staphylococci.