Coherent connections of brain biopotentials in military personnel during recovery from mine-blast closed craniocerebral injuries.

OBJECTIVE

Aim: To investigate interhemispheric and intrahemispheric coherence of brain biopotentials in military personnel during the recovery period following mineblast closed craniocerebral injuries (MBCCI), as well as to assess the cumulative effect of repeated injuries on coherence patterns.

PATIENTS AND

METHODS

Materials and

Methods

The study included 28 military personnel with single (14 patients) and multiple (14 patients) MBCCIs, along with 11 healthy controls without neurotrauma. Background electroencephalograms recorded prior to treatment initiation were subjected to coherence analysis.

RESULTS

Results

Demonstrated a significant reduction in both inter- and intrahemispheric coherence in military personnel with single, and particularly multiple, MBCCIs, indicating impaired integrative brain functioning. In both groups of injured military personnel, the most pronounced reductions in interhemispheric coherence relative to healthy controls were observed within the delta, theta, alpha, and low-beta frequency bands, predominantly in the frontal and parietal regions. Multiple MBCCIs were associated with generalized interhemispheric dysfunction across all frequency bands, involving the central, occipital, and temporal regions, as well as an imbalance of intrahemispheric coherence-manifested as suppressed activity in the left hemisphere and compensatory hyperactivation in the right. These alterations in coherence parameters correlated with clinical manifestations of neurological, emotional, and cognitive impairments, reflecting varying degrees of functional reserve depletion in military personnel with single and multiple MBCCIs.

CONCLUSION

Conclusions

The findings may serve as a basis for the development of pathogenetically grounded, individualized neurorehabilitation programs.