Development and validation of a harmonized memory score for multicenter Alzheimer's disease and related dementia research.
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Ошибки и ограничения
История · было → стало
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Sanderson-Cimino Mark, Gross Alden L, Gaynor Leslie S, Paolillo Emily W, Saloner Rowan, Albert Marilyn S, Apostolova Liana G, Boersema Brooke, Boxer Adam L, Boeve Bradley F, Casaletto Kaitlin B, Heuer Hilary W, Forsberg Leah K, Hallgarth Savannah R, Diaz Valentina E, Clark Lindsay R, Eloyan Ani, Farias Sarah Tomaszewski, Maillard Pauline, Gonzales Mitzi M, Hammers Dustin B, La Joie Renaud, Cobigo Yann, Wolf Amy, Hampstead Benjamin M, Mechanic-Hamilton Dawn, Miller Bruce L, Rabinovici Gil D, Ringman John M, D'Orazio Lina M, Rosen Howie J, Ryman Sephira G, Prestopnik Jillian L, Salmon David P, Smith Glenn E, DeCarli Charles, Rajan Kumar B, Jin Lee-Way, Hinman Jason D, Johnson David K, Harvey Danielle J, Fornage Myriam, Carrillo Maria C, Dickerson Bradford C, Kramer Joel H, Staffaroni Adam M, ALLFTD consortium, MarkVCID study, LEADS consortium, and Diverse Vascular Contributions to Cognitive Impairment and Dementia (Diverse VCID) Study Investigators
Аннотация
METHODS: Item-banking confirmatory factor analysis was applied to develop a memory composite in a diagnostically heterogeneous sample (n = 8716) that completed the UDS-NB and one of five LLTs. Construct validity was evaluated through associations with demographics, disease severity, cognitive tasks, brain volume, amyloid/tau PET positivity, and plasma phosphorylated tau. Analyses were replicated in a racially/ethnically diverse cohort (n = 839).
RESULTS: Psychometric properties were adequate. Expected associations with demographics and clinical measures within development and validation cohorts supported validity.
CONCLUSIONS: This composite supports memory research across cohorts that administer the UDS and LLTs. A user-friendly UI is freely available to create the score in other datasets.