Endocrine research · 2026
Early treatment responses in childhood Graves' disease: factors affecting the normalization period of thyroid hormones.
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Erbaş İbrahim Mert, Çelik Ezgi, Kırkgöz Tarık, Nalbantoğlu Özlem, Korkmaz Hüseyin Anıl, Özkan Behzat
Аннотация
OBJECTIVE: Herein, we aimed to reveal the factors affecting the early treatment responses and the normalization process of thyroid hormone levels in childhood Graves' disease..
METHODS: This retrospective study included 46 pediatric patients who were diagnosed with Graves' disease and started treatment during a period of 10 years, and whose at least one of their free T3 (fT3) or free T4 (fT4) levels decreased to the reference range during follow-up.
RESULTS: The normalization time of fT3 and fT4 were 5 (3-8) and 3.5 (2-7) weeks after the treatment initiation, respectively. Gender, age, pubertal status, presence of goiter, ophthalmopathy or tachycardia, basal thyroid hormone levels, initial dose of methimazole, and addition of beta-blockers did not show an effect on the normalization time of either fT3 or fT4 (p > 0.05). In those under the age of 12 (n = 15) with a high TRAb titer (>10 IU/L), the time for normalization of fT3 was longer (p = 0.024), and in those with ophthalmopathy, this process was longer for fT4 (p = 0.017).
CONCLUSIONS: By these results, we showed that early treatment response and the normalization period of thyroid hormones were not related to the initial treatment dose.
METHODS: This retrospective study included 46 pediatric patients who were diagnosed with Graves' disease and started treatment during a period of 10 years, and whose at least one of their free T3 (fT3) or free T4 (fT4) levels decreased to the reference range during follow-up.
RESULTS: The normalization time of fT3 and fT4 were 5 (3-8) and 3.5 (2-7) weeks after the treatment initiation, respectively. Gender, age, pubertal status, presence of goiter, ophthalmopathy or tachycardia, basal thyroid hormone levels, initial dose of methimazole, and addition of beta-blockers did not show an effect on the normalization time of either fT3 or fT4 (p > 0.05). In those under the age of 12 (n = 15) with a high TRAb titer (>10 IU/L), the time for normalization of fT3 was longer (p = 0.024), and in those with ophthalmopathy, this process was longer for fT4 (p = 0.017).
CONCLUSIONS: By these results, we showed that early treatment response and the normalization period of thyroid hormones were not related to the initial treatment dose.