Prevalence of group A rotavirus G and P genotypes in children with acute gastroenteritis in China from 2020 to 2021.

In China, inpatient/outpatient visits for rotavirus (RV)-associated diarrhea are common among children aged < 5 years. An interim analysis evaluated RV genotype circulation in China in an ongoing observational effectiveness study of a pentavalent (RV5) vaccine. Data were collected (October 2020-March 2021) from children eligible for vaccination with three doses of RV5 and receiving treatment for acute gastroenteritis. RV gastroenteritis was reported in 494 (62.1%) of the 796 children tested (median age, 15 months). The circulating genotypes were G9 (81.8%), G2 (5.5%), G8 (4.6%), and G3 (0.4%); no G1 or G4 genotypes were detected. The most common genotype combinations were G9P[8] and G2P[4].