Neuromotor changes in postural control following bed rest.

Chronic bed rest (BR) serves as a model for studying the effects of prolonged immobility on physiological and neuromotor functions, particularly postural control. Prolonged BR leads to significant deconditioning of postural balance control, characterized by increased sway path lengths, sway velocity and fall risk, independent of muscle strength. These changes are linked to neural adaptations at spinal and supraspinal levels, including structural and functional brain changes, such as alterations in grey and white matter, increased cerebellar activation, reduced spinal excitability and increased latencies within reflex circuitries. Additionally, BR disrupts sensory integration from proprioceptive, visual and vestibular systems, impairing postural stability. Visual reliance remains stable during BR, though decreased visual acuity and contrast sensitivity are noted. Moreover, BR-induced shifts in cerebrospinal fluid contribute to altered brain activity, impacting sensorimotor function. Vestibular system adaptations, including changes in vestibulospinal reflexes, further exacerbate balance impairments. Understanding these mechanisms is crucial for developing interventions to mitigate the adverse effects of BR on postural control and prevent prolonged recovery times or increased risk of injury. This review highlights the need for further research into the neural underpinnings of BR-induced postural instability, with a focus on sensory integration and neuroplasticity.