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Войти в исследования Head & neck · 2026
Dysphagia Rehabilitation Outcomes in Head and Neck Cancer Patients With Radiation Associated Dysphagia: Does Time Since (Chemo)radiation Matter?
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Massonet Hanne, Goeleven Ann, Nuyts Sandra, Vergauwen Alice, Van Haesendonck Gilles, Baudelet Margot, Duprez Fréderic, Tomassen Peter, Everaert Marthe, Meulemans Jeroen, Poorten Vincent Vander, Van Rompaey Diane, Mariën Steven, Vanderveken Olivier, Van den Steen Leen, Van Nuffelen Gwen
Аннотация
BACKGROUND: Since radiation-associated dysphagia may evolve in the months to years following (chemo)radiotherapy (C/RT), it is important to determine whether swallowing-related outcomes vary according to the time elapsed since cancer treatment. This may help to determine the time window in which a patient might benefit most from dysphagia rehabilitation.
METHODS: Fifty-four patients were stratified into three groups based on the time since completion of the C/RT: < 1 year; 1-5 years; > 5 years post-C/RT. Differences in swallowing-related outcomes were compared at baseline and after 8 weeks of swallowing rehabilitation.
RESULTS: Swallowing-related outcomes were significantly worse at baseline in patients who were more than 5 years post-C/RT compared to those less than 5 years post-C/RT. Nevertheless, these patients still show significant and comparable improvements in swallowing-related outcomes after 8 weeks of swallowing rehabilitation.
CONCLUSIONS: Although patients more than 5 years post-C/RT exhibited worse swallowing-related outcomes compared to those less than 5 years post-C/RT, these patients remain viable candidates for swallowing rehabilitation.
TRIAL REGISTRATION: ClinicalTrials.gov identifier: ISRCTN57028065.
METHODS: Fifty-four patients were stratified into three groups based on the time since completion of the C/RT: < 1 year; 1-5 years; > 5 years post-C/RT. Differences in swallowing-related outcomes were compared at baseline and after 8 weeks of swallowing rehabilitation.
RESULTS: Swallowing-related outcomes were significantly worse at baseline in patients who were more than 5 years post-C/RT compared to those less than 5 years post-C/RT. Nevertheless, these patients still show significant and comparable improvements in swallowing-related outcomes after 8 weeks of swallowing rehabilitation.
CONCLUSIONS: Although patients more than 5 years post-C/RT exhibited worse swallowing-related outcomes compared to those less than 5 years post-C/RT, these patients remain viable candidates for swallowing rehabilitation.
TRIAL REGISTRATION: ClinicalTrials.gov identifier: ISRCTN57028065.