Human Campylobacter spp. infections in Italy.
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Zerbato Verena, Di Bella Stefano, Pol Riccardo, Luzzati Roberto, Sanson Gianfranco, Ambretti Simone, Andreoni Stefano, Aschbacher Richard, Bernardo Mariano, Bielli Alessandra, Brigante Gioconda, Busetti Marina, Camarlinghi Giulio, Carcione Davide, Carducci Antonella, Clementi Nicola, Carretto Edoardo, Chilleri Chiara, Codda Giulia, Consonni Alessandra, Costantino Venera, Cortazzo Venere, Di Santolo Manuela, Dodaro Saveria, Fiori Barbara, García-Fernández Aurora, Foschi Claudio, Gobbato Elisa, Greco Francesca, La Ragione Roberto Marcello, Mancini Nicasio, Maraolo Alberto Enrico, Marchese Anna, Marcuccio Daniela, Marrollo Roberta, Mauri Carola, Mazzariol Annarita, Morroni Gianluca, Mosca Adriana, Nigrisoli Giacomo, Pagani Elisabetta, Parisio Eva Maria, Pollini Simona, Sarti Mario, Sorrentino Annarita, Trotta Domenico, Villa Laura, Vismara Chiara, Principe Luigi
Аннотация
METHODS: Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry. Antibiograms were determined with Etest or Kirby-Bauer (EUCAST criteria).
RESULTS: In total, 5419 isolations of Campylobacter spp. were performed. The most common species were C. jejuni (n = 4535, 83.7%), followed by C. coli (n = 732, 13.5%) and C. fetus (n = 34, 0.6%). The mean age of patients was 34.61 years and 57.1% were males. Outpatients accounted for 54% of the cases detected. Campylobacter were isolated from faeces in 97.3% of cases and in 2.7% from blood. C. fetus was mostly isolated from blood (88.2% of cases). We tested for antimicrobial susceptibility 4627 isolates (85.4%). Resistance to ciprofloxacin and tetracyclines was 75.5% and 54.8%, respectively; resistance to erythromycin was 4.8%; clarithromycin 2% and azithromycin 2%. 50% of C. jejuni and C. coli were resistant to ≥ 2 antibiotics. Over the study period, resistance to ciprofloxacin and tetracyclines significantly decreased (p < 0.005), while resistance to macrolides remained stable.
CONCLUSION: Campylobacter resistance to fluoroquinolones and tetracyclines in Italy is decreasing but is still high, while macrolides retain good activity.