[Development of Clinical Practice and Clinical Pharmacy Research toward the Appropriate Use of Medications].

We have engaged in clinical practice and pharmaceutical research aimed at the appropriate use of medications. In pharmacist-to-pharmacist collaboration using medication guidance information-sharing documents, it was possible to monitor treatment efficacy and adverse effects through sharing clinical data, or making prescription proposals. Our hospital's pharmacist services contributed to expanding the calculation of drug management and guidance fees by pharmacists in clinics with beds. The drug interaction that occurred between enteric-coated omeprazole tablets and Maalox® granules suggested the possibility of an unexpected drug interaction through a mechanism distinct from that reported for fluoroquinolones and Maalox® suspension. It has been suggested that certain components of black vinegar strongly inhibit P-glycoprotein (P-gp) function in the intestines, potentially enhancing the absorption of P-gp substrates. It has been suggested that aojiru strongly binds to cationic drugs with cyclic structures, significantly reducing their absorption. Based on these findings, we will continue to conduct pharmaceutical research in clinical practice and promote the appropriate use of medications.