Percutaneous Ultrasound-Guided Intratumoral Injection of Lauromacrogol and Pingyangmycin in the Treatment of Advanced pPNET in Children.

OBJECTIVES

To evaluate real-time ultrasound-guided intratumoral lauromacrogol + pingyangmycin for pediatric peripheral primitive neuroectodermal tumors (pPNET) refractory to chemotherapy.

METHODS

Five tumor lesions in three children from our institution were treated under real-time ultrasound guidance. Color Doppler and contrast-enhanced ultrasound assessed tumor hemodynamics and size pre- and post- injection.

RESULTS

Pre-injection, all tumors showed rich blood flow (mixed arteriovenous signals). Post-injection contrast ultrasound revealed significantly reduced arterial-phase blood supply. At 4-week follow-up, all five tumors showed statistically significant volume reduction (p < 0.05) and reduced tumor-related pain. No adverse reactions such as bleeding and pain occurred during injection.

CONCLUSION

Ultrasound-guided intratumoral lauromacrogol + pingyangmycin injection effectively reduces tumor blood supply, destroys local vasculature, and shrinks tumor volume in end-stage pediatric pPNET. It is a safe and effective local palliative treatment.