Mutations of Two Major Coagulation Factors Are Not Associated with Male Infertility.

BACKGROUND

Thrombophilia-related mutations, such as coagulation factor V Leiden and factor II (G20210A), have been associated with female infertility due to spontaneous abortions during pregnancy. The possible role of mutations of these two factors in male infertility has not been studied to date.

MATERIALS AND

METHODS

A total of 208 unrelated Greek men were investigated, including 108 infertile men with idiopathic oligozoospermia, azoospermia, and oligozoospermia of various etiologies, as well as 100 fertile male controls. DNA extracted from participants' sperm or blood was analyzed for factor V Leiden and factor II G20210A mutations.

RESULTS

There were no significant differences in factor V and factor II genotypes between infertile men and normal controls.

CONCLUSION

An association of the two common thrombophilia-related mutations with male infertility was not observed in this preliminary study.