Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2009
[Study of methylation of promoter of EYA1 gene in microtia].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lin Lin, Pan Bo, Jiang Hai-yue, Zhuang Hong-xing, Zhao Yan-yong, Yang Qing-hua, He Le-ren, Han Juan, Wang Shu-jie
Аннотация
OBJECTIVE: To explore the methylation of CpG islands in promoter of eye absent gene 1 (EYA1) in microtia.
METHODS: The methylation of CpG islands in EYA1 gene in 64 microtias and 36 healthy controls were measured using the technique of matrix-assisted laser desorption/ionization-time of flight.
RESULTS: The methylation of CpG_Unit3 and CpG_Unit5 of EYA1 gene in microtia were 0.09258 +/- 0.033846 and 0.0922 +/- 0.02379, respectively, which were significantly lower than those in control.
CONCLUSIONS: Hypomethylation in microtia may be related to the pathogenesis of the disease.
METHODS: The methylation of CpG islands in EYA1 gene in 64 microtias and 36 healthy controls were measured using the technique of matrix-assisted laser desorption/ionization-time of flight.
RESULTS: The methylation of CpG_Unit3 and CpG_Unit5 of EYA1 gene in microtia were 0.09258 +/- 0.033846 and 0.0922 +/- 0.02379, respectively, which were significantly lower than those in control.
CONCLUSIONS: Hypomethylation in microtia may be related to the pathogenesis of the disease.