The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2009
Humoral immune deficiency and hemifacial microsomia seen in one family.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Mikhak Zamaneh, Mulliken John B, Lee John, Bonilla Francisco A, Kimonis Virginia E
Аннотация
We present a patient with hemifacial microsomia and immune deficiency. The patient is a 5-year-old with grade III microtia and Pruzansky type I right mandibular hypoplasia. She developed 25 pulmonary infections in 3 years, required hospitalization every 6 weeks to receive antibiotics, and experienced recurrent herpes stomatitis and esophagitis, staphylococcal bacteremia, urinary tract, sinus, and ear infections. She had low total IgG, IgG1, IgG2, IgA, and anti-pneumococcal antibody levels. She was unable to maintain protective pneumococcal titers following vaccination. The patient's 7-year-old sister also suffered from recurrent infections, had a left facial skin tag, and a left arachnoid cyst. We conclude that immune deficiency can occur in association with hemifacial microsomia.