[Effects of carbon disulfide on neurotransmitter and its metabolites in rats].

OBJECTIVE

In order to study the mechanism of neurotoxic effects of carbon disulfide (CS2) on animal behavior.

METHODS

Changes in monoamine transmitter, amino acid transmitter and their metabolites in brain tissues were observed in rats exposed to CS2 at levels of 0, 1,200 and 2,400 mg/m3 respectively, for two months, with high performance liquid chromatography.

RESULTS

Indicated that exposure to CS2 could cause decrease in 3-methoxy-4-hydroxy mandelic acid (VMA), increase in 3,4-dioxybenzoic acid, a metabolite of dopamine, and high vanillic acid in rat straitum, decrease in excitatory amino acids and their metabolites (glutamine, aspartic acid and asparagine), with a certain relationship between contents of VMA, aspartic acid and asparagine and changes in neurobehavior.

CONCLUSION

Disturbance of neurotransmitter metabolism plays an important role in neurotoxic effects of CS2.