Journal of pediatric surgery · 2012
Cholestasis and growth in neonates with gastroschisis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Fallon Erica M, Mitchell Paul D, Potemkin Alexis K, Nehra Deepika, Arsenault Danielle A, Robinson Elizabeth M, Zurakowski David, Brenn Megan, Meisel Jonathan A, Puder Mark
Аннотация
PURPOSE: The aim of this study was to determine the incidence of cholestasis and the correlation between cholestasis and weight-for-age z scores in parenteral nutrition-dependent neonates with gastroschisis.
METHODS: A single-center retrospective review of 59 infants born with gastroschisis from January 2000 to June 2007 was conducted. Demographic and clinical data were collected and analyzed. Subjects were divided into cholestatic and noncholestatic groups. Statistical analyses included the Student t test, Wilcoxon rank sum test, Fisher exact test, and a general linear model.
RESULTS: Fifty-nine neonates with gastroschisis were identified, and 16 (28%) of 58 patients developed cholestasis. Younger gestational age and cholestasis were found to be independently associated with weight-for-age z score in 30 of 58 patients with available long-term follow-up data.
CONCLUSIONS: Parenteral nutrition-dependent neonates with gastroschisis remain at considerable risk for the development of cholestasis. Both gestational age and cholestasis were found to be independent risk factors, predisposing these neonates to poor postnatal growth.
METHODS: A single-center retrospective review of 59 infants born with gastroschisis from January 2000 to June 2007 was conducted. Demographic and clinical data were collected and analyzed. Subjects were divided into cholestatic and noncholestatic groups. Statistical analyses included the Student t test, Wilcoxon rank sum test, Fisher exact test, and a general linear model.
RESULTS: Fifty-nine neonates with gastroschisis were identified, and 16 (28%) of 58 patients developed cholestasis. Younger gestational age and cholestasis were found to be independently associated with weight-for-age z score in 30 of 58 patients with available long-term follow-up data.
CONCLUSIONS: Parenteral nutrition-dependent neonates with gastroschisis remain at considerable risk for the development of cholestasis. Both gestational age and cholestasis were found to be independent risk factors, predisposing these neonates to poor postnatal growth.
Предметные рубрики MeSH
Abdominal Wound Closure TechniquesBirth WeightBody WeightCholestasisFemaleGastroschisisGestational AgeGrowth DisordersHumansIncidenceInfant, NewbornInfant, PrematureInfant, Premature, DiseasesIntestinal DiseasesLength of StayLiver TransplantationMaleParenteral NutritionPostoperative ComplicationsRetrospective StudiesRisk FactorsSepsis