Analytica chimica acta · 2025
Fluorescence detection of phenylethylamine based on Cucurbit[7]uril supramolecular assemblies.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sun Yan, Yuan Shang-Wei, Chen Qing, Chen Dan-Ping, Xu Xue-Yang, Tao Zhu, Xiao Xin
Аннотация
BACKGROUND: Phenethylamine (PEA) is a novel psychoactive substance that can cause agitation and hallucinations, posing a threat to human health. In this study, a N1@Q[7] supramolecular assembly with a robust fluorescent probe effect was prepared through the supramolecular self-assembly of cucurbit[7]uril (Q[7]) and a bromophenylpyridine derivative (N1).
RESULTS: In this supramolecular assembly, the isoquinoline moiety of N1 entered the cavity of Q[7], while the 4,4-bromophenylpyridyl moiety remained outside, forming a 1:1 inclusion complex. It was found that the addition of other amines did not significantly affect the fluorescence of the assembly, but the addition of PEA caused a notable decrease in fluorescence intensity and a red shift. N1@Q[7] demonstrated sensitive specificity and high selectivity to PEA. The principle is that PEA molecules, N1 molecules, and Q[7] form a synergistic ternary system. Based on this, the detection of PEA in real urine samples by N1@Q[7] was simulated.
SIGNIFFCANCE AND NOVELTY: The probe exhibited high selectivity in the presence of major components of real urine and enabled visual detection of PEA through fluorescence color change at different concentrations. This study provides a new fluorescent probe method for the detection of drugs and their metabolites.
RESULTS: In this supramolecular assembly, the isoquinoline moiety of N1 entered the cavity of Q[7], while the 4,4-bromophenylpyridyl moiety remained outside, forming a 1:1 inclusion complex. It was found that the addition of other amines did not significantly affect the fluorescence of the assembly, but the addition of PEA caused a notable decrease in fluorescence intensity and a red shift. N1@Q[7] demonstrated sensitive specificity and high selectivity to PEA. The principle is that PEA molecules, N1 molecules, and Q[7] form a synergistic ternary system. Based on this, the detection of PEA in real urine samples by N1@Q[7] was simulated.
SIGNIFFCANCE AND NOVELTY: The probe exhibited high selectivity in the presence of major components of real urine and enabled visual detection of PEA through fluorescence color change at different concentrations. This study provides a new fluorescent probe method for the detection of drugs and their metabolites.