The Journal of nutrition · 2026
Antidiabetic Kidney Disease Benefits of Feeding Rice Starch/Inulin-Enriched Extruded Rice to Diabetes Homozygous Mice.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sun Aoyue, Sun Chengbin, Gao Wei, Tao Haiteng, Zhao Haibo, Yu Bin, Zhang Zheng, Liu Pengfei, Cui Bo
Аннотация
BACKGROUND: Diabetic kidney disease (DKD) is the commonest cause of end-stage kidney disease. Supplementation of dietary fiber may have potential benefits for patients with DKD.
OBJECTIVES: This study developed a type of functional extruded rice (FER) with rice starch and 10% inulin using twin-screw extrusion, and its beneficial effects on DKD mice were evaluated.
METHODS: Mice were divided into control (CON) group (diabetes heterozygous mice fed a normal diet containing extruded rice starch without inulin), model (MOD) group [diabetic MOD, diabetes homozygous mice (db/db) mice fed a normal diet containing extruded rice starch without inulin], FER-fed (RERF) group (db/db mice fed a normal diet containing FER), and metformin-treated group (positive CON, db/db mice treated with metformin and fed a normal diet containing extruded rice starch without inulin).
RESULTS: Physicochemical analysis revealed that resistant starch content was significantly increased by 403.57% in FER compared with extruded rice starch without inulin, which was caused by inulin-starch interactions. Compared with the MOD group, the FER-fed (RERF) group decreased fasting blood glucose by 32.70%, serum creatinine by 50.96%, urea nitrogen by 26.89%, tumor necrosis factor-α by 34.98%, and interleukin-6 by 37.70% (P < 0.05). Histopathology results showed reduced glomerular swelling and colon inflammation in the RERF group compared with the MOD group. Consumption of the FER diet reshaped the profile of gut microbiota, increasing abundances of short-chain fatty acid-producing Anaerostipes and reducing proinflammatory Alistipes. Compared with the MOD group, the RERF group increased acetic acid by 86.88%, propanoic acid by 154.08%, and butanoic acid by 319.56% (P < 0.05).
CONCLUSIONS: These findings indicate that FER could be utilized as a food for special dietary use in patients with diabetic kidney, given the dietary fiber-enriched rice's ability to mitigate DKD in an appropriate mouse disease MOD.
OBJECTIVES: This study developed a type of functional extruded rice (FER) with rice starch and 10% inulin using twin-screw extrusion, and its beneficial effects on DKD mice were evaluated.
METHODS: Mice were divided into control (CON) group (diabetes heterozygous mice fed a normal diet containing extruded rice starch without inulin), model (MOD) group [diabetic MOD, diabetes homozygous mice (db/db) mice fed a normal diet containing extruded rice starch without inulin], FER-fed (RERF) group (db/db mice fed a normal diet containing FER), and metformin-treated group (positive CON, db/db mice treated with metformin and fed a normal diet containing extruded rice starch without inulin).
RESULTS: Physicochemical analysis revealed that resistant starch content was significantly increased by 403.57% in FER compared with extruded rice starch without inulin, which was caused by inulin-starch interactions. Compared with the MOD group, the FER-fed (RERF) group decreased fasting blood glucose by 32.70%, serum creatinine by 50.96%, urea nitrogen by 26.89%, tumor necrosis factor-α by 34.98%, and interleukin-6 by 37.70% (P < 0.05). Histopathology results showed reduced glomerular swelling and colon inflammation in the RERF group compared with the MOD group. Consumption of the FER diet reshaped the profile of gut microbiota, increasing abundances of short-chain fatty acid-producing Anaerostipes and reducing proinflammatory Alistipes. Compared with the MOD group, the RERF group increased acetic acid by 86.88%, propanoic acid by 154.08%, and butanoic acid by 319.56% (P < 0.05).
CONCLUSIONS: These findings indicate that FER could be utilized as a food for special dietary use in patients with diabetic kidney, given the dietary fiber-enriched rice's ability to mitigate DKD in an appropriate mouse disease MOD.