Revista medica del Instituto Mexicano del Seguro Social · 2022
[Levosimendan for preventing low output syndrome in pediatric patients with correction of tetralogy of Fallot].
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Gutiérrez-Riveroll Karla Itzel, Mejía Picazo Héctor Jorge, Dosta-Herrera Juan José
Аннотация
BACKGROUND: Tetralogy of Fallot is one of the most frequent cyanotic heart diseases in our country, occupying the second place reported by the national health program 2007- 2012 and its prevalence is around 11%. Patients undergoing correction for tetralogy of Fallot are considered patients with a prolonged ischemic time and a high risk of presenting low cardiac output syndrome.
OBJECTIVE: To compare levosimendan with milrinone to prevent low cardiac output syndrome in patients undergoing tetralogy of Fallot correction.
MATERIAL AND METHODS: Randomized controlled open, prospective, longitudinal and comparative clinical trial. The sample size consisted of 19 patients, with a 95% confidence level. Group 1: levosimendan 0.1 mcg/kg/min from anesthetic induction. Group 2: conventional management with milrinone 0.5 mcg/kg/min.
RESULTS: When comparing the final measurements, it can be observed that the mean arterial pressure of the intervention group (levosimendan) was statistically significant (p = 0.04), both in the intraoperative measurement and in the final measurement. When comparing uresis, we found that the intervention group had a greater amount of uresis (p = 0.03). Regarding lactate, both in the intraoperative measurement (p = 0.002) and in the final measurement (p = 0.02), a lower amount was found in the intervention group.
CONCLUSIONS: The results in favor of the use of levosimendan were reported, demonstrating the prevention of low cardiac output syndrome.
OBJECTIVE: To compare levosimendan with milrinone to prevent low cardiac output syndrome in patients undergoing tetralogy of Fallot correction.
MATERIAL AND METHODS: Randomized controlled open, prospective, longitudinal and comparative clinical trial. The sample size consisted of 19 patients, with a 95% confidence level. Group 1: levosimendan 0.1 mcg/kg/min from anesthetic induction. Group 2: conventional management with milrinone 0.5 mcg/kg/min.
RESULTS: When comparing the final measurements, it can be observed that the mean arterial pressure of the intervention group (levosimendan) was statistically significant (p = 0.04), both in the intraoperative measurement and in the final measurement. When comparing uresis, we found that the intervention group had a greater amount of uresis (p = 0.03). Regarding lactate, both in the intraoperative measurement (p = 0.002) and in the final measurement (p = 0.02), a lower amount was found in the intervention group.
CONCLUSIONS: The results in favor of the use of levosimendan were reported, demonstrating the prevention of low cardiac output syndrome.