BMC ophthalmology · 2006
Randomised controlled single-blind study of conventional versus depot mydriatic drug delivery prior to cataract surgery.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Dubois Vincent, Wittles Nadia, Lamont Meon, Madge Simon, Luck Jon
Аннотация
BACKGROUND: A prerequisite for safe cataract surgery is an adequately dilated pupil. The authors conducted a trial to assess the efficacy (in terms of pupil diameter) of a depot method of pre-operative pupil dilatation, as compared with repeated instillations of drops (which is time-consuming for the nursing staff and uncomfortable for the patient).
METHODS: A prospective randomised masked trial was conducted comprising 130 patients with no significant ocular history undergoing elective clear corneal phacoemulsification. 65 patients had mydriatic drops (Tropicamide 1%, Phenylephrine 2.5%, Diclofenac sodium 0.1%) instilled prior to surgery, 65 had a wick soaked in the same drop mixture placed in the inferior fornix. Horizontal pupil diameters were recorded on a millimetre scale immediately prior to surgery.
RESULTS: There was no significant difference in pupil size between the two groups (p = 0.255, Student's t-test).
CONCLUSION: There was no significant difference between the mydriasis obtained with the depot system compared with conventional drop application. Use of a depot mydriatic delivery system appears to be a safe and efficient method of drug delivery.
TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number Register ISRCTN78047760.
METHODS: A prospective randomised masked trial was conducted comprising 130 patients with no significant ocular history undergoing elective clear corneal phacoemulsification. 65 patients had mydriatic drops (Tropicamide 1%, Phenylephrine 2.5%, Diclofenac sodium 0.1%) instilled prior to surgery, 65 had a wick soaked in the same drop mixture placed in the inferior fornix. Horizontal pupil diameters were recorded on a millimetre scale immediately prior to surgery.
RESULTS: There was no significant difference in pupil size between the two groups (p = 0.255, Student's t-test).
CONCLUSION: There was no significant difference between the mydriasis obtained with the depot system compared with conventional drop application. Use of a depot mydriatic delivery system appears to be a safe and efficient method of drug delivery.
TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number Register ISRCTN78047760.