Multiple sclerosis and related disorders · 2026
Brain and posture: Insights into neural activation and postural control in people with multiple sclerosis.
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Gervasoni Elisa, Torchio Alessandro, Bonilauri Augusto, Corrini Chiara, Sangiuliano Intra Francesca, Baglio Francesca, Cattaneo Davide
Аннотация
BACKGROUND: Balance impairments are common in people with Multiple Sclerosis (PwMS), yet brain activity during ecologically valid balance tasks is poorly understood.
OBJECTIVE: To compare hemodynamic responses and postural control between PwMS and healthy subjects(HS) during a task forcing a greater reliance on vestibular cues.
METHODS: In this cross-sectional study, 18 PwMS (median[IQR] age: 44.0(17.5) years, EDSS: 2.0(1.0)) and 18 age-sex-matched HS underwent fNIRS recordings while standing on a foam with eyes closed. Oxy- and deoxyhemoglobin changes were recorded over frontal, occipital, and temporo-parietal cortices, while body sway Area was measured using a stabilometric platform. A linear mixed-effects model tested Group, Brodmann area(BA), hemisphere Side and body sway Area effects.
RESULTS: PwMS showed greater sway than HS (1965.9[2027.8]mm²; 1306.7[572.2]mm², p=.04). A significant four-way interaction emerged between Group, BA, Side, and Area (F(df1,df2) =16.76,p<.0001; conditional-R²=0.89). HS exhibited larger responses than PwMS in bilateral BA40 (HS-PwMS; left:0.45±0.14 µM,p=.003; right:0.57±0.14 µM,p=.003), and BA21-22 (left:0.58±0.14 µM,p=.0002; right:0.45±0.14 µM, p=.003). Associations between sway Area and cortical activity were stronger in HS, with significant slopes in BA21-22, BA40 bilaterally and left BA18 (p<.01).
CONCLUSIONS: Temporal-parietal activity is a key contributor to maintaining balance control. PwMS showed weaker hemodynamic responses in sensory-challenging conditions less associated to postural instability compared to HS, suggesting altered cortical involvement in balance control.
TRIAL REGISTRY: Protocol code: 20190119. Date of ethical approval: 2020/10/19).
OBJECTIVE: To compare hemodynamic responses and postural control between PwMS and healthy subjects(HS) during a task forcing a greater reliance on vestibular cues.
METHODS: In this cross-sectional study, 18 PwMS (median[IQR] age: 44.0(17.5) years, EDSS: 2.0(1.0)) and 18 age-sex-matched HS underwent fNIRS recordings while standing on a foam with eyes closed. Oxy- and deoxyhemoglobin changes were recorded over frontal, occipital, and temporo-parietal cortices, while body sway Area was measured using a stabilometric platform. A linear mixed-effects model tested Group, Brodmann area(BA), hemisphere Side and body sway Area effects.
RESULTS: PwMS showed greater sway than HS (1965.9[2027.8]mm²; 1306.7[572.2]mm², p=.04). A significant four-way interaction emerged between Group, BA, Side, and Area (F(df1,df2) =16.76,p<.0001; conditional-R²=0.89). HS exhibited larger responses than PwMS in bilateral BA40 (HS-PwMS; left:0.45±0.14 µM,p=.003; right:0.57±0.14 µM,p=.003), and BA21-22 (left:0.58±0.14 µM,p=.0002; right:0.45±0.14 µM, p=.003). Associations between sway Area and cortical activity were stronger in HS, with significant slopes in BA21-22, BA40 bilaterally and left BA18 (p<.01).
CONCLUSIONS: Temporal-parietal activity is a key contributor to maintaining balance control. PwMS showed weaker hemodynamic responses in sensory-challenging conditions less associated to postural instability compared to HS, suggesting altered cortical involvement in balance control.
TRIAL REGISTRY: Protocol code: 20190119. Date of ethical approval: 2020/10/19).