A Bibliometric and Visual Analysis of Oliceridine Research (2013-2024).

PURPOSE: To explore and analyze the current research progress, hotspots, and future trends in oliceridine research using bibliometric methods.

PATIENTS AND

METHODS

We searched the Web of Science (WOS) database utilizing the keywords TS = ("oliceridine*" OR "TRV 130*" OR "TRV-130*" OR "olinvyk*" OR "TRV130*" OR "C22H31CIN2O2S*") for relevant research literature on oliceridine from its inception to June 16, 2024. Bibliometric methods were applied, and analysis software such as VOSviewer and CiteSpace were used to visualize the publication timeline, authors, countries and regions, keywords, sources of literature, research hotspots, and co-cited documents related to oliceridine. Co-occurrence and aggregation analyses were conducted, and maps relevant to institutional cooperation were generated.

RESULTS

A total of 151 relevant articles were retrieved and included in the final analysis. Most articles were published between 2020 and 2021. The United States has the highest number of publications and citations in this field. Molecular structure development is a pivotal point in this field. Research hotspots were diverse, including acute pain, opioid receptors, β-arrestin, postoperative pain, therapeutic window, respiratory depression, clinical trials, and chronic pain.

CONCLUSION

Oliceridine, a newly developed analgesic, has garnered global interest. The USA is a leading contributor to this field. Recent research has shifted from basic studies to clinical practice.