Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia.
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Hara Akinori, Wada Takashi, Muso Eri, Maruyama Shoichi, Kato Sawako, Furuichi Kengo, Yoshimura Kenichi, Toyama Tadashi, Sakai Norihiko, Suzuki Hiroyuki, Tsukamoto Tatsuo, Miyazaki Mariko, Sato Eiichi, Abe Masanori, Shibagaki Yugo, Narita Ichiei, Goto Shin, Sakamaki Yuichi, Yokoyama Hitoshi, Mori Noriko, Tanaka Satoshi, Yuzawa Yukio, Hasegawa Midori, Matsubara Takeshi, Wada Jun, Tanabe Katsuyuki, Masutani Kosuke, Abe Yasuhiro, Tsuruya Kazuhiko, Fujimoto Shouichi, Iwatsubo Shuji, Tsuda Akihiro, Suzuki Hitoshi, Kasuno Kenji, Terada Yoshio, Nakata Takeshi, Iino Noriaki, Sofue Tadashi, Miyata Hitomi, Nakano Toshiaki, Ohtake Takayasu, Kobayashi Shuzo, LICENSE study group
Аннотация
METHODS: In this nationwide multicenter prospective study, we enrolled 40 patients with diabetes. Inclusion criteria were proteinuria (defined as an albumin/creatinine ratio ≥3 g/g), serum creatinine levels <2 mg/dL, and serum LDL ≥120 mg/dL despite drug treatment. LDL apheresis was performed 6-12 times within 12 weeks. The 36-item Short Form Health Survey (SF-36) was used to analyze QoL.
RESULTS: The study enrolled 35 patients (27 men and 8 women; mean age 58.9 ± 11.9 years). A comparison of baseline SF-36 values with those at the end of the course of apheresis found an improvement in the mean physical component summary (37.9 ± 11.4 vs. 40.6 ± 10.5, p = 0.051) and a significant increase in the mean mental component summary (MCS) (49.4 ± 8.4 vs. 52.5 ± 10.9, p = 0.026). A multivariable linear regression analysis revealed a history of coronary heart disease negatively correlated with the MCS increase at the end of the course of apheresis (β coefficient -6.935, 95% confidence interval, 13.313 to-0.556, p = 0.034).
CONCLUSION: Our results suggest that LDL apheresis may improve the mental and physical QoL in patients with diabetes, proteinuria, and hypercholesterolemia.