Nature genetics · 2022
Discovery of 42 genome-wide significant loci associated with dyslexia.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Doust Catherine, Fontanillas Pierre, Eising Else, Gordon Scott D, Wang Zhengjun, Alagöz Gökberk, Molz Barbara, 23andMe Research Team, Quantitative Trait Working Group of the GenLang Consortium, Pourcain Beate St, Francks Clyde, Marioni Riccardo E, Zhao Jingjing, Paracchini Silvia, Talcott Joel B, Monaco Anthony P, Stein John F, Gruen Jeffrey R, Olson Richard K, Willcutt Erik G, DeFries John C, Pennington Bruce F, Smith Shelley D, Wright Margaret J, Martin Nicholas G, Auton Adam, Bates Timothy C, Fisher Simon E, Luciano Michelle
Аннотация
Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.