Journal of clinical anesthesia · 2013
Effects of postoperative epidural analgesia on recurrence-free and overall survival in patients with nonsmall cell lung cancer.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Cata Juan P, Gottumukkala Vijaya, Thakar Dilip, Keerty Dinesh, Gebhardt Rodolfo, Liu Diane D
Аннотация
STUDY OBJECTIVE: To determine whether postoperative epidural analgesia is associated with better recurrence-free survival and overall survival after lung cancer surgery.
DESIGN: Retrospective study.
SETTING: Academic hospital.
MEASUREMENTS: Data of patients with stage 1, stage 2, and stage 3 nonsmall cell lung cancer, who underwent tumor resection surgery, were studied. Patient data were grouped into three different postoperative pain management interventions: intravenous patient-controlled analgesia, patient-controlled epidural analgesia, and their combination. Univariate and multicovariate Cox proportional hazards models were applied to assess the effects of covariates of interest on overall survival and recurrence-free survival.
MAIN RESULTS: The type of postoperative analgesia used for patients who underwent surgery for nonsmall cell lung cancer did not affect recurrence-free survival or overall survival. However, certain variables, including age ≥ 65 years, male gender, body mass index ≥ 25 kg/m(2), ASA physical status 4, and the need for preoperative blood transfusions, pneumonectomy, and postoperative radiation, were associated with decreased recurrence-free survival and overall survival.
CONCLUSIONS: The type of postoperative analgesia used after surgery for nonsmall cell lung cancer is not associated with better 2-year or 5-year recurrence-free survival or overall survival rates.
DESIGN: Retrospective study.
SETTING: Academic hospital.
MEASUREMENTS: Data of patients with stage 1, stage 2, and stage 3 nonsmall cell lung cancer, who underwent tumor resection surgery, were studied. Patient data were grouped into three different postoperative pain management interventions: intravenous patient-controlled analgesia, patient-controlled epidural analgesia, and their combination. Univariate and multicovariate Cox proportional hazards models were applied to assess the effects of covariates of interest on overall survival and recurrence-free survival.
MAIN RESULTS: The type of postoperative analgesia used for patients who underwent surgery for nonsmall cell lung cancer did not affect recurrence-free survival or overall survival. However, certain variables, including age ≥ 65 years, male gender, body mass index ≥ 25 kg/m(2), ASA physical status 4, and the need for preoperative blood transfusions, pneumonectomy, and postoperative radiation, were associated with decreased recurrence-free survival and overall survival.
CONCLUSIONS: The type of postoperative analgesia used after surgery for nonsmall cell lung cancer is not associated with better 2-year or 5-year recurrence-free survival or overall survival rates.
Предметные рубрики MeSH
Age FactorsAgedAmidesAnalgesia, EpiduralAnalgesia, Patient-ControlledAnalgesics, OpioidAnesthetics, LocalBody Mass IndexBupivacaineCarcinoma, Non-Small-Cell LungDrug Therapy, CombinationFemaleFentanylFollow-Up StudiesHealth StatusHumansHydromorphoneLungLung NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalPain ManagementPostoperative PainProportional Hazards ModelsRetrospective StudiesRopivacaineSex FactorsSurvival RateTreatment Outcome