Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease.
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Yang Yisu, Lorenz Anna, Sathe Aditi, Schilling Kurt G, Gaynor Leslie S, Choi Seo-Eun, Lee Michael L, Scollard Phoebe, Trittschuh Emily H, Mukherjee Shubhabrata, Mez Jesse, Dumitrescu Logan C, Landman Bennett A, Crane Paul K, Cuccaro Michael L, Hohman Timothy J, Archer Derek B
Аннотация
INTRODUCTION: Memory is a strong endophenotype for Alzheimer's disease (AD) but is typically detectable only after substantial brain change. Genetically linking late-life memory with mid-life brain traits may identify early markers of AD-related cognitive decline.
METHODS: We leveraged GeNetic cOVariance Analyzer (GNOVA) to estimate genetic covariance between genome-wide association studies (GWASs) of memory performance (MEM) and decline (memslopes) and 3935 UK Biobank (UKB) imaging-derived phenotypes (IDPs) across diffusion, structural, and functional modalities, stratifying by cognitive status and apolipoprotein E (APOE) inclusion. Memory GWASs included 24,216 non-Hispanic White older adults (mean = 74.46 years); IDP GWASs included 33,224 European-ancestry mid-life participants (45.1 to 81.8 years, mean = 64.28).
RESULTS: Diffusion and structural IDPs in medial temporal and frontal regions showed the strongest genetic covariance with memory, with additional shared genetic architecture in default mode network functional connectivity.
DISCUSSION: Mid-life brain traits genetically linked to late-life memory map to AD-vulnerable regions, suggesting biologically relevant risk pathways and potential drug targets for cognitive decline.
METHODS: We leveraged GeNetic cOVariance Analyzer (GNOVA) to estimate genetic covariance between genome-wide association studies (GWASs) of memory performance (MEM) and decline (memslopes) and 3935 UK Biobank (UKB) imaging-derived phenotypes (IDPs) across diffusion, structural, and functional modalities, stratifying by cognitive status and apolipoprotein E (APOE) inclusion. Memory GWASs included 24,216 non-Hispanic White older adults (mean = 74.46 years); IDP GWASs included 33,224 European-ancestry mid-life participants (45.1 to 81.8 years, mean = 64.28).
RESULTS: Diffusion and structural IDPs in medial temporal and frontal regions showed the strongest genetic covariance with memory, with additional shared genetic architecture in default mode network functional connectivity.
DISCUSSION: Mid-life brain traits genetically linked to late-life memory map to AD-vulnerable regions, suggesting biologically relevant risk pathways and potential drug targets for cognitive decline.