Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.

Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) often share multiple similar symptoms and are highly comorbid; however, the common and distinct brain neuroanatomy of these two diseases are unclear. The current study attempted to identify the overlapping and different gray matter volume (GMV) between AN and OCD. We conducted a voxel-wise meta-analysis of GMV using the latest Seed-based d Mapping with Permutation of Subject Images Toolbox (SDM-PSI) software. Compared to healthy controls, patients with AN showed reduced GMV in supplementary motor areas, median cingulate cortices, the left cerebellum, right Rolandic operculum (RO), right insula, right superior temporal gyrus (STG), and right precuneus, while OCD patients were characterized by low GMV in the right insula, STG, RO, and inferior frontal gyrus (IFG). The conjunctional analysis indicated that these two disorders have overlapping structural abnormalities in the right insula, STG, RO and IFG. No distinct GMV alteration was found. These common structural brain abnormalities may underlie the neuropathology of the similar neuropsychological features and highly comorbid manifestations of AN and OCD.