Journal of psychiatric research · 2026
Diurnal variation in antipsychotic-associated acute dystonia: A retrospective cohort study.
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Hamers P J, Bakker B, Dries L, Dieleman S, Bouter D C, Grootendorst-van Mil N H
Аннотация
BACKGROUND: Acute dystonia is a distressing adverse effect of antipsychotics. A circadian pattern has been suggested, but evidence is limited.
OBJECTIVE: To investigate whether antipsychotic-induced acute dystonia shows a time-of-day distribution.
METHODS: We conducted a retrospective review of patients admitted to a first-episode psychosis ward (2017-2025). The timing of dystonia onset was extracted from clinical records. Temporal clustering was assessed using circular statistics (Rayleigh test) and Chi-square analyses of predefined time blocks.
RESULTS: Thirty-five cases of acute dystonia were identified (mean age 22.4 years, SD 4.1; 71.4% male). Events clustered in the afternoon and early evening (mean time 5:12 p.m.; Rayleigh R = 0.71, p < 0.001). Chi-square tests confirmed deviation from uniformity (p < 0.001). Sensitivity analyses showed that results were independent of antipsychotic dosing time, time to reaction, and antipsychotic dose.
CONCLUSION: Acute dystonia onset appeared to cluster in the late afternoon and early evening, warranting further investigation of time-of-day effects in monitoring antipsychotic-related motor effects.
OBJECTIVE: To investigate whether antipsychotic-induced acute dystonia shows a time-of-day distribution.
METHODS: We conducted a retrospective review of patients admitted to a first-episode psychosis ward (2017-2025). The timing of dystonia onset was extracted from clinical records. Temporal clustering was assessed using circular statistics (Rayleigh test) and Chi-square analyses of predefined time blocks.
RESULTS: Thirty-five cases of acute dystonia were identified (mean age 22.4 years, SD 4.1; 71.4% male). Events clustered in the afternoon and early evening (mean time 5:12 p.m.; Rayleigh R = 0.71, p < 0.001). Chi-square tests confirmed deviation from uniformity (p < 0.001). Sensitivity analyses showed that results were independent of antipsychotic dosing time, time to reaction, and antipsychotic dose.
CONCLUSION: Acute dystonia onset appeared to cluster in the late afternoon and early evening, warranting further investigation of time-of-day effects in monitoring antipsychotic-related motor effects.