Scandinavian cardiovascular journal : SCJ · 2012
Cardiac troponin I in congenital heart defects with pressure or volume overload.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Eerola Anneli, Jokinen Eero O, Savukoski Tanja I, Pettersson Kim S I, Poutanen Tuija, Pihkala Jaana I
Аннотация
OBJECTIVE: To evaluate the prevalence of cardiac troponin I (cTnI) and autoantibodies to cTn in children with congenital heart defects with volume or pressure overload fulfilling the criteria for treatment, and in healthy children.
DESIGN: The study groups comprised 78 children with volume overload caused by an atrial septal defect or a patent ductus arteriosus, and 60 children with pressure overload caused by coarctation of the aorta or stenosis of the aortic or the pulmonary valve, and 74 healthy controls. Serum levels of natriuretic peptides, cTnI, and autoantibodies to cTn were analyzed at baseline, prior to treatment and in 64 patients 6 months after treatment.
RESULTS: At baseline, one child with volume overload, 12 children with pressure overload, and one healthy control had positive cTnI. Further analysis of the pressure overload subgroup revealed that the children with positive cTnI were younger than those with negative cTnI, and had higher levels of natriuretic peptides. The pressure gradient at the coarctation site or stenotic valve was higher in those with positive TnI. Six months after treatment, 63 of 64 children examined were cTnI negative.
CONCLUSIONS: The cTnI release is more frequently associated with pressure than volume overload which resolves after treatment in most children.
DESIGN: The study groups comprised 78 children with volume overload caused by an atrial septal defect or a patent ductus arteriosus, and 60 children with pressure overload caused by coarctation of the aorta or stenosis of the aortic or the pulmonary valve, and 74 healthy controls. Serum levels of natriuretic peptides, cTnI, and autoantibodies to cTn were analyzed at baseline, prior to treatment and in 64 patients 6 months after treatment.
RESULTS: At baseline, one child with volume overload, 12 children with pressure overload, and one healthy control had positive cTnI. Further analysis of the pressure overload subgroup revealed that the children with positive cTnI were younger than those with negative cTnI, and had higher levels of natriuretic peptides. The pressure gradient at the coarctation site or stenotic valve was higher in those with positive TnI. Six months after treatment, 63 of 64 children examined were cTnI negative.
CONCLUSIONS: The cTnI release is more frequently associated with pressure than volume overload which resolves after treatment in most children.
Предметные рубрики MeSH
AdolescentAortic CoarctationAortic Valve StenosisAtrial Natriuretic FactorAutoantibodiesBiomarkersCase-Control StudiesChildChild, PreschoolDuctus Arteriosus, PatentFemaleHeart Defects, CongenitalHeart FailureHeart Septal Defects, AtrialHemodynamicsHumansInfantInfant, NewbornMaleNatriuretic Peptide, BrainPeptide FragmentsPrognosisProspective StudiesPulmonary Valve StenosisTime FactorsTroponin IYoung Adult