Fertility and sterility · 2012
Maternal fecundity and asthma among offspring-is the risk programmed preconceptionally? Retrospective observational study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Harju Maijakaisa, Keski-Nisula Leea, Raatikainen Kaisa, Pekkanen Juha, Heinonen Seppo
Аннотация
OBJECTIVE: To evaluate the association between maternal fecundity factors and time to pregnancy and risk of asthma in offspring.
DESIGN: Retrospective observational hospital-based birth cohort study.
SETTING: A university-based obstetrics and gynecology department.
PATIENT(S): A total of 40,914 women, who delivered between 1989 and 2007, were linked with the register for asthma reimbursement (n = 2,577) for their offspring. Fecundity factors were recorded during pregnancy. Logistic regression analyses were used.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Asthma among offspring.
RESULT(S): The risk of asthma was significantly increased if the mother had any infertility problems (adjusted odds ratio [adjusted OR] 1.39, 95% confidence interval [CI] 1.19-1.63), medical infertility treatment (aOR 1.43, 95% CI 1.13-1.80), or any infertility treatment (aOR 1.50, 95% CI 1.26-1.79). The risk of asthma among offspring was also higher among mothers who had more than two miscarriages (aOR 1.25, 95% CI 1.04-1.51) and time to pregnancy over 3 months (aOR 1.25, 95% CI 1.07-1.45).
CONCLUSION(S): These findings suggest that maternal subfertility exposes offspring to an increased risk of asthma.
CLINICAL TRIAL REGISTRATION NUMBER: The study is registered in Kuopio University Hospital register (TUTKI): ID 5302448.
DESIGN: Retrospective observational hospital-based birth cohort study.
SETTING: A university-based obstetrics and gynecology department.
PATIENT(S): A total of 40,914 women, who delivered between 1989 and 2007, were linked with the register for asthma reimbursement (n = 2,577) for their offspring. Fecundity factors were recorded during pregnancy. Logistic regression analyses were used.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Asthma among offspring.
RESULT(S): The risk of asthma was significantly increased if the mother had any infertility problems (adjusted odds ratio [adjusted OR] 1.39, 95% confidence interval [CI] 1.19-1.63), medical infertility treatment (aOR 1.43, 95% CI 1.13-1.80), or any infertility treatment (aOR 1.50, 95% CI 1.26-1.79). The risk of asthma among offspring was also higher among mothers who had more than two miscarriages (aOR 1.25, 95% CI 1.04-1.51) and time to pregnancy over 3 months (aOR 1.25, 95% CI 1.07-1.45).
CONCLUSION(S): These findings suggest that maternal subfertility exposes offspring to an increased risk of asthma.
CLINICAL TRIAL REGISTRATION NUMBER: The study is registered in Kuopio University Hospital register (TUTKI): ID 5302448.