Brain & development · 2025
COVID-19 infection and vaccination in children with Dravet syndrome or infantile epileptic spasms syndrome: An internet survey in Japan.
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Ito Susumu, Nishikawa Aiko, Kuroiwa Ruby, Honda Kaori, Nagata Satoru
Аннотация
BACKGROUND: This study aimed to clarify the status of coronavirus disease 2019 (COVID-19) infection and vaccination among children with infantile-onset drug-resistant epilepsy through an internet survey involving Dravet syndrome (DS) and infantile epileptic spasms syndrome (IESS) family associations.
METHODS: A web-based survey was conducted between October and November 2023, targeting parents of children aged ≤15 years with DS or IESS who were members of the Dravet Syndrome JP or West Syndrome JP family associations, covering patient characteristics, COVID-19 infection, and vaccination.
RESULTS: A total of 151 and 112 responses were obtained. COVID-19 infections occurred in 68.2 % and 52.7 % of DS and IESS cases, respectively. Fever-triggered seizures were reported in 61.8 % of DS and 3.6 % of IESS cases. Among DS cases, 22.8 % (8.0 % vaccinated), 36.6 % (20.0 % vaccinated), and 34.0 % (16.0 % vaccinated) required temporary visits for seizure exacerbation, emergency visits for seizure clusters/status epilepticus, and seizure-related hospitalizations, respectively. Vaccination rates were 25.3 % for DS and 17.3 % for IESS. Post-vaccination fever-triggered seizures occurred in 2.9 % and 3.5 % of DS cases after the first and second doses, respectively, and 0.0 % of IESS cases. Among DS cases, temporary visits were required in 2.9 % and 0.0 %, emergency visits in 0.0 % for both doses and hospitalizations in 2.9 % and 3.5 %, respectively. Vaccine hesitancy arising from seizure concerns was reported by 66.4 % and 23.0 % of DS and IESS caregivers, respectively.
CONCLUSION: COVID-19 vaccination is well-tolerated and may lower seizure risks in children with DS. However, caregivers should monitor those with a history of fever-triggered seizures.
METHODS: A web-based survey was conducted between October and November 2023, targeting parents of children aged ≤15 years with DS or IESS who were members of the Dravet Syndrome JP or West Syndrome JP family associations, covering patient characteristics, COVID-19 infection, and vaccination.
RESULTS: A total of 151 and 112 responses were obtained. COVID-19 infections occurred in 68.2 % and 52.7 % of DS and IESS cases, respectively. Fever-triggered seizures were reported in 61.8 % of DS and 3.6 % of IESS cases. Among DS cases, 22.8 % (8.0 % vaccinated), 36.6 % (20.0 % vaccinated), and 34.0 % (16.0 % vaccinated) required temporary visits for seizure exacerbation, emergency visits for seizure clusters/status epilepticus, and seizure-related hospitalizations, respectively. Vaccination rates were 25.3 % for DS and 17.3 % for IESS. Post-vaccination fever-triggered seizures occurred in 2.9 % and 3.5 % of DS cases after the first and second doses, respectively, and 0.0 % of IESS cases. Among DS cases, temporary visits were required in 2.9 % and 0.0 %, emergency visits in 0.0 % for both doses and hospitalizations in 2.9 % and 3.5 %, respectively. Vaccine hesitancy arising from seizure concerns was reported by 66.4 % and 23.0 % of DS and IESS caregivers, respectively.
CONCLUSION: COVID-19 vaccination is well-tolerated and may lower seizure risks in children with DS. However, caregivers should monitor those with a history of fever-triggered seizures.