The Journal of emergency medicine · 2026
The Diagnostic Efficacy of Thiol-Disulfide Homeostasis in Sepsis Patients.
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Alaçam Mehmet, Yürümez Yusuf, Yazar Hayrullah, Güner Necip Gökhan, Arslan Nuray
Аннотация
BACKGROUND: Sepsis is a life-threatening condition with high mortality and complex pathophysiology that requires urgent diagnosis and treatment. Oxidative stress and disturbances in redox balance play a significant role in its pathogenesis. Thiol-disulfide homeostasis is a biochemical marker of oxidative stress and may have diagnostic potential in sepsis.
OBJECTIVES: This study aimed to evaluate the diagnostic value of thiol-disulfide homeostasis in sepsis patients and its relationship with inflammatory markers and mortality.
METHODS: Fifty sepsis patients and fifty age- and sex-matched healthy controls were included. Serum levels of total thiol, native thiol, disulfide, reduced thiol, and oxidized thiol were measured. Inflammatory markers, including C-reactive protein (CRP), procalcitonin, and lactate, were also assessed. Group comparisons and correlation analyses were performed.
RESULTS: In the sepsis group, total thiol, native thiol, disulfide, and reduced thiol levels were significantly lower, while oxidized thiol levels and thiol oxidation-reduction ratios were significantly higher compared to controls. CRP, procalcitonin, and lactate levels were markedly elevated in sepsis patients. A negative correlation was observed between CRP and thiol-disulfide ratios. No significant association was found between thiol-disulfide homeostasis parameters and 30-day mortality.
CONCLUSIONS: Thiol-disulfide homeostasis parameters may serve as useful biomarkers in the diagnosis of sepsis but do not appear to predict mortality. Larger-scale studies are warranted to validate their clinical applicability and prognostic value.
OBJECTIVES: This study aimed to evaluate the diagnostic value of thiol-disulfide homeostasis in sepsis patients and its relationship with inflammatory markers and mortality.
METHODS: Fifty sepsis patients and fifty age- and sex-matched healthy controls were included. Serum levels of total thiol, native thiol, disulfide, reduced thiol, and oxidized thiol were measured. Inflammatory markers, including C-reactive protein (CRP), procalcitonin, and lactate, were also assessed. Group comparisons and correlation analyses were performed.
RESULTS: In the sepsis group, total thiol, native thiol, disulfide, and reduced thiol levels were significantly lower, while oxidized thiol levels and thiol oxidation-reduction ratios were significantly higher compared to controls. CRP, procalcitonin, and lactate levels were markedly elevated in sepsis patients. A negative correlation was observed between CRP and thiol-disulfide ratios. No significant association was found between thiol-disulfide homeostasis parameters and 30-day mortality.
CONCLUSIONS: Thiol-disulfide homeostasis parameters may serve as useful biomarkers in the diagnosis of sepsis but do not appear to predict mortality. Larger-scale studies are warranted to validate their clinical applicability and prognostic value.