Revista de neurologia · 2001
[Extrarenal effects of furosemide on normal and ischemic cerebral tissue in the rat].
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Oria De Suárez C, Eblen Zajjur A
Аннотация
INTRODUCTION: Recent studies suggest that furosemide (FUR), a chloride cotransporting antagonist, acts directly on neurons of central nervous system modifying the ionic flow.
OBJECTIVE: The aim of the present study was to determine the extrarenal antiedema effect of FUR.
MATERIAL AND METHODS: Male Sprague-Dawley rats were anesthetized with tiobarbital (60 mg/kg-1 ip), bilaterally nephrectomized and perfunded iv with solution of Ringer (RIN) (n= 5) or FUR (40 mg/kg-1) (n= 6), in equivalent volumes. The diuretic effect of FUR was excluded by bilateral nephrectomy. Two tungsten microelectrodes implanted on the cerebral cortex, registered the tissue impedance by the voltage fall of a square wave electric pulse (100 mA, 10 ms) tested every 120 seconds, before and after infusion of FUR or RIN and during global cerebral ischemia by D-tubocurarine induced respiratory arrest.
RESULTS: Preischemic FUR infusion induced a significant increase of voltage (t= 15.68; p< 0.0001). During global cerebral ischemia, the voltage fall was significantly lower in FUR than for RIN infusion (Wilcoxon Z= 3.9; p< 0.00001).
CONCLUSION: These results suggest that FUR reduced significantly the cerebral impedance i.e. antiedema effect, by an extrarenal action, under both basal and ischemia conditions.
OBJECTIVE: The aim of the present study was to determine the extrarenal antiedema effect of FUR.
MATERIAL AND METHODS: Male Sprague-Dawley rats were anesthetized with tiobarbital (60 mg/kg-1 ip), bilaterally nephrectomized and perfunded iv with solution of Ringer (RIN) (n= 5) or FUR (40 mg/kg-1) (n= 6), in equivalent volumes. The diuretic effect of FUR was excluded by bilateral nephrectomy. Two tungsten microelectrodes implanted on the cerebral cortex, registered the tissue impedance by the voltage fall of a square wave electric pulse (100 mA, 10 ms) tested every 120 seconds, before and after infusion of FUR or RIN and during global cerebral ischemia by D-tubocurarine induced respiratory arrest.
RESULTS: Preischemic FUR infusion induced a significant increase of voltage (t= 15.68; p< 0.0001). During global cerebral ischemia, the voltage fall was significantly lower in FUR than for RIN infusion (Wilcoxon Z= 3.9; p< 0.00001).
CONCLUSION: These results suggest that FUR reduced significantly the cerebral impedance i.e. antiedema effect, by an extrarenal action, under both basal and ischemia conditions.