The Journal of nutrition · 2026
Effect of Gut Microbiota from Patients with Uremia on Body Weight and Microinflammation in Rats.
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Liu Yong-Zhan, Cui Xiang-Fei, Mao Si-Yu
Аннотация
BACKGROUND: Gut dysbiosis is associated with malnutrition and inflammation in chronic kidney disease (CKD); however, the causality remains unclear.
OBJECTIVES: This study aimed to determine whether fecal microbiota from patients with stage 5 CKD can directly induce nutritional impairment and inflammatory responses in recipient rats.
METHODS: Fecal microbiota from patients with stage 5 CKD and healthy controls were transplanted into rats treated with antibiotics. After 2 weeks, we assessed nutritional parameters, inflammatory markers, and microbial composition.
RESULTS: Compared with the healthy-fecal microbiota transplantation (FMT) group, rats receiving CKD-derived microbiota exhibited a significant reduction in body weight (466.70 ± 12.60 g compared with 433.90 ± 20.10 g) and serum albumin concentrations (22.87 ± 5.43 g/L compared with 20.36 ± 7.51 g/L). In contrast, serum inflammatory markers were significantly elevated in the CKD-FMT group, including C-reactive protein (12.10 ± 3.10 mg/L compared with 15.40 ± 5.00 mg/L) and interleukin-6 (14.30 ± 1.80 pg/L compared with 18.80 ± 2.10 pg/L) (all P < 0.05). Microbial analysis revealed enrichment of Enterobacteriaceae and depletion of beneficial genera such as Lactobacillus and Ruminococcaceae.
CONCLUSIONS: Our results provide direct evidence that gut microbiota from patients with uremia can impair nutritional status and aggravate systemic inflammation in recipient rats, underscoring a pathogenic role of dysbiosis in CKD complications.
OBJECTIVES: This study aimed to determine whether fecal microbiota from patients with stage 5 CKD can directly induce nutritional impairment and inflammatory responses in recipient rats.
METHODS: Fecal microbiota from patients with stage 5 CKD and healthy controls were transplanted into rats treated with antibiotics. After 2 weeks, we assessed nutritional parameters, inflammatory markers, and microbial composition.
RESULTS: Compared with the healthy-fecal microbiota transplantation (FMT) group, rats receiving CKD-derived microbiota exhibited a significant reduction in body weight (466.70 ± 12.60 g compared with 433.90 ± 20.10 g) and serum albumin concentrations (22.87 ± 5.43 g/L compared with 20.36 ± 7.51 g/L). In contrast, serum inflammatory markers were significantly elevated in the CKD-FMT group, including C-reactive protein (12.10 ± 3.10 mg/L compared with 15.40 ± 5.00 mg/L) and interleukin-6 (14.30 ± 1.80 pg/L compared with 18.80 ± 2.10 pg/L) (all P < 0.05). Microbial analysis revealed enrichment of Enterobacteriaceae and depletion of beneficial genera such as Lactobacillus and Ruminococcaceae.
CONCLUSIONS: Our results provide direct evidence that gut microbiota from patients with uremia can impair nutritional status and aggravate systemic inflammation in recipient rats, underscoring a pathogenic role of dysbiosis in CKD complications.