International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Positive predictive value of respiratory infection diagnoses in the Danish National Patient Registry: A post hoc validation analysis of the DANFLU-1 trial.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Christensen Jacob, Johansen Niklas Dyrby, Bernholm Katrine Feldballe, Borchsenius Julie Inge-Marie Helene, Janstrup Kira Hyldekær, Modin Daniel, Skaarup Kristoffer Grundtvig, Nealon Joshua, Samson Sandrine, Loiacono Matthew, Huang Youjun, Harris Rebecca, Larsen Carsten Schade, Jensen Anne Marie Reimer, Landler Nino Emanuel, Claggett Brian L, Solomon Scott D, Gislason Gunnar H, Køber Lars, Landray Martin J, Sivapalan Pradeesh, Jensen Jens Ulrik Stæhr, Biering-Sørensen Tor
Аннотация
OBJECTIVES: To validate respiratory infection diagnosis codes in the Danish National Patient Registry (DNPR) in the DANFLU-1 feasibility trial, and to assess whether reperforming effectiveness analyses with validated events altered findings.
METHODS: Hospitalizations for influenza or pneumonia (International Classification of Diseases, Tenth Revision codes J09-18) were validated against medical record review by two blinded physicians. Events were validated against (i) medical opinion and (ii) diagnostic criteria of symptomatology combined with laboratory or radiological verification. Positive predictive values (PPVs) were calculated along with relative vaccine effectiveness (rVE) of high-dose (HD) vs standard-dose (SD) influenza vaccines.
RESULTS: Among 12,477 participants, we identified 43 events in the DNPR (influenza J09-11: n = 3, pneumonia J12-18: n = 40), which demonstrated PPVs of 86% (95% confidence interval: 72-95%) and 91% (78-97%) against the medical opinion of the respective reviewers. Against diagnostic criteria, the PPVs were 65% (49-79%) and 67% (51-81%). For influenza codes, the PPV was 100% according to reviewers and references and between 63% and 90%, depending on reviewer and reference for pneumonia. The rVE consistently favored HD vs SD against validated events.
CONCLUSION: Hospitalizations for pneumonia registered in the DNPR may benefit from subsequent validation, warranting further studies. HD influenza vaccination was associated with fewer validated events than SD.
TRIAL REGISTRATION: Clinicaltrials.gov: NCT05048589.
METHODS: Hospitalizations for influenza or pneumonia (International Classification of Diseases, Tenth Revision codes J09-18) were validated against medical record review by two blinded physicians. Events were validated against (i) medical opinion and (ii) diagnostic criteria of symptomatology combined with laboratory or radiological verification. Positive predictive values (PPVs) were calculated along with relative vaccine effectiveness (rVE) of high-dose (HD) vs standard-dose (SD) influenza vaccines.
RESULTS: Among 12,477 participants, we identified 43 events in the DNPR (influenza J09-11: n = 3, pneumonia J12-18: n = 40), which demonstrated PPVs of 86% (95% confidence interval: 72-95%) and 91% (78-97%) against the medical opinion of the respective reviewers. Against diagnostic criteria, the PPVs were 65% (49-79%) and 67% (51-81%). For influenza codes, the PPV was 100% according to reviewers and references and between 63% and 90%, depending on reviewer and reference for pneumonia. The rVE consistently favored HD vs SD against validated events.
CONCLUSION: Hospitalizations for pneumonia registered in the DNPR may benefit from subsequent validation, warranting further studies. HD influenza vaccination was associated with fewer validated events than SD.
TRIAL REGISTRATION: Clinicaltrials.gov: NCT05048589.
Предметные рубрики MeSH
AdolescentAdultAgedChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedYoung AdultDenmarkHospitalizationInfluenza VaccinesInfluenza, HumanInternational Classification of DiseasesPneumoniaPredictive Value of TestsRegistriesRespiratory Tract InfectionsVaccine EfficacyMulticenter Studies as TopicRandomized Controlled Trials as Topic