Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2004
TTV infection in children with and without liver disease.
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Odemis Ender, Gurakan Figen, Ergunay Koray, Yuce Aysel, Ozen Hasan, Kocak Nurten
Аннотация
BACKGROUND: TTV DNA has been reported in patients with a broad spectrum of hepatic disorders as well as in healthy people.
AIM: To clarify the role of TTV in children with liver disease and in healthy children.
METHODS: Degenerate primers designed to amplify a target sequence from the ORF 1 region of TTV genome were used for nested PCR, to detect TTV DNA in sera.
RESULTS: TTV was detected in 3 of 18 children with chronic hepatitis B (16.7%), 2 of 17 hepatitis B carriers (11.8%), 2 of 17 children with cryptogenic chronic liver disease (11.8%), and 1 of 40 (2.5%) children without liver disease. The infection rate was similar among the various study groups and in the various age groups. There was no difference between TTV positive and negative children in respect to gender, history of surgery, parenteral treatment, transfusion of blood and blood products, presence of hepatomegaly, splenomegaly, jaundice, and transaminase values.
CONCLUSION: TTV does not seem to have an etiologic role in cryptogenic liver disease in children and does not seem to influence the clinical course of liver disease.
AIM: To clarify the role of TTV in children with liver disease and in healthy children.
METHODS: Degenerate primers designed to amplify a target sequence from the ORF 1 region of TTV genome were used for nested PCR, to detect TTV DNA in sera.
RESULTS: TTV was detected in 3 of 18 children with chronic hepatitis B (16.7%), 2 of 17 hepatitis B carriers (11.8%), 2 of 17 children with cryptogenic chronic liver disease (11.8%), and 1 of 40 (2.5%) children without liver disease. The infection rate was similar among the various study groups and in the various age groups. There was no difference between TTV positive and negative children in respect to gender, history of surgery, parenteral treatment, transfusion of blood and blood products, presence of hepatomegaly, splenomegaly, jaundice, and transaminase values.
CONCLUSION: TTV does not seem to have an etiologic role in cryptogenic liver disease in children and does not seem to influence the clinical course of liver disease.
Предметные рубрики MeSH
Age DistributionCase-Control StudiesChildChild, PreschoolCohort StudiesDNA Virus InfectionsDNA, ViralFemaleHepatitis B, ChronicHepatitis, Viral, HumanHumansLiver Function TestsMalePolymerase Chain ReactionPrevalencePrognosisReference ValuesRisk AssessmentSeverity of Illness IndexSex DistributionStatistics, NonparametricTorque teno virusTurkey