Neuropsychological assessments in a large cohort of pediatric palliative epilepsy surgery patients.
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Jeno M, Koop J, Gabriel M, Caraway A, Novotny E, Patrick K, Gonzalez-Giraldo E, Auguste K, Ostendorf A, McNally K, Alexander A, Berrios-Servios G, Eschbach K, Bolton J, Ailion A, Singh R, Wong-Kisiel L, Zaccariello M, Tatachar P, Duong P, Depositario-Cabacar D, Berl M, Sepeta L, Karakas C, Karia S, Mohapatra L, Rowmanowski E, McNamara N, Hodges E, Shrey D, Hennrick H, Olaya J, Arredondo K, DeLeon R, Reddy S, Molnar A, Javarayee P, Park S E, Coryell J, Olsen E, Bearden D J, Winston M, Samanta D, Armstrong D, Wolf S, McGoldrick P, Marashly A, Grinspan Z, Nangia S, Perry M, Ciliberto M
Аннотация
METHODS: Data was collected from the PERC surgical database, a collaboration of pediatric epilepsy centers prospectively enrolling pediatric patients undergoing epilepsy surgery evaluation. Pediatric patients with DRE who sought care at PERC centers, underwent first-time palliative epilepsy surgery, and had neurocognitive data collected were included.
RESULTS: 569 patients had complete data with some form of neuropsychological assessment documented. Patients with focal motor (0.42 [CI 95% 0.28, 0.62] < 0.01) or cognitive delays (0.20 [CI 95% 0.13, 0.31] < 0.01) were less likely to receive neuropsychological testing, as were those with genetic etiology (0.5x, [CI 95% 0.33, 0.75] p < 0.01). The number of domains evaluated within corpus callosotomy (CC) (median 3, (1-9) < 0.01) and hemispherectomy (median 4 (1-9) < 0.01) groups was significantly lower than testing in other surgical groups. In addition the cognitive IQ and adaptive IQ were lower in patients undergoing CC and compared to other groups.
CONCLUSIONS: All types of patients undergoing palliative epilepsy surgery had some neuropsychological testing. However, those with lower IQ and those undergoing CC or hemispherectomy were less likely to undergo testing. Reduced rates of testing in certain groups indicates room for improvement, especially given recommendations to use testing to help determine surgical success.