Wei sheng yan jiu = Journal of hygiene research · 2010
[Expression changes of glutathione transferase omega 1 induced by low dose trichloroethylene].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Huang Haiyan, Zhuang Zhixiong, Liu Jianjun, Xi Renrong, Xing Xiumei
Аннотация
OBJECTIVE: To determine the expression of glutathione transferase omega 1 (GSTO-1) during hormesis induced by low dose trichloroethylene (TCE).
METHODS: Based on the dose-response of hormesis induced by TCE, the total protein and mRNA from four groups was extracted, and expression of GSTO-1 was detected by western blotting and RT-PCR technology.
RESULTS: The study showed that increases of GSTO-1 protein expression were induced by TCE at low dose (0.1 mmol/L) TCE, but there was no significant different between the high-dose group and the control (P < 0.05). RT-PCR analysis presented the expression of GSTO-1 gene in low-dose group was increased, but the opposite effect was observed in the high-dose group.
CONCLUSION: GSTO-1 may be play a key role in hormesis induced by TCE.
METHODS: Based on the dose-response of hormesis induced by TCE, the total protein and mRNA from four groups was extracted, and expression of GSTO-1 was detected by western blotting and RT-PCR technology.
RESULTS: The study showed that increases of GSTO-1 protein expression were induced by TCE at low dose (0.1 mmol/L) TCE, but there was no significant different between the high-dose group and the control (P < 0.05). RT-PCR analysis presented the expression of GSTO-1 gene in low-dose group was increased, but the opposite effect was observed in the high-dose group.
CONCLUSION: GSTO-1 may be play a key role in hormesis induced by TCE.