Tight orchestration of wound healing phase through metal-organic compounds.

Cutaneous wound healing remains a common health problem. Metal-organic frameworks (MOFs) have emerged as an advanced therapeutic platform for promoted wound healing. However, there is a lack of MOF particles possessing excellent stability, biocompatibility, and reactive oxygen species (ROS) scavenging ability for tight orchestration of wound healing. Herein, we synthetize therapeutic MOF particles named PgC3Zn and employ them as skin sprays for wound repair. At the inflammatory stage, the pH- and ROS-responsive Zn2+ release of PgC3Zn alleviates oxidative stress and exerts antibacterial and anti-inflammatory efficacy. During the proliferation stage, PgC3Zn promote the migration and proliferation of fibroblasts, the re-epithelialization of keratinocytes, and the angiogenesis of endothelial cells. During the remodeling stage, PgC3Zn effectively facilitate the wound closure and collagen deposition. Moreover, multiple endogenous growth factors have been identified to contribute to the wound healing process. Importantly, PgC3Zn exhibit excellent biocompatibility and remarkably accelerate the healing process in both acute and infected rat full-thickness skin wound models in vivo. Consistently, transcriptomic data illustrate the multi-stage and multi-functional regulation effects of PgC3Zn in promoting wound healing. This study proposes versatile and biocompatible PgC3Zn MOF particles with potentials for enhancing the management of acute and infected skin wounds.