Medicina oral, patologia oral y cirugia bucal · 2026
Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects.
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Gil-Montoya J-A, Gerez-Muñoz M-J, Triviño-Ibáñez E-M, Rosel E, Bravo M, Rómero-Fábrega J-C, Morales-Santana S, Gómez-Río M
Аннотация
BACKGROUND: Lactoferrin in saliva has been proposed as a possible diagnostic biomarker for Alzheimer's disease, as it is associated with ß-amyloid load in the brain. The aim of this study was to find out whether there is an association between salivary lactoferrin and cerebral ß-amyloid load and the involvement of periodontal disease in this possible connection.
MATERIAL AND METHODS: Six exploratory comparison groups were designed: participants with mild cognitive impairment (n=50) (positive PET-amyloid with and without periodontal disease and negative PET-amyloid with and without periodontal disease) and cognitively normal older individuals with and without periodontal disease (n=19). All participants were recruited from referral hospitals in Granada, Spain, and from a nursing home in the same socio-economic area as the hospital participants. A salivary lactoferrin determination and a periodontal assessment has been performed in each of the participants.
RESULTS: The results show that both having an atypical ß-amyloid load in the brain (PET+) and having periodontal disease are clearly associated with a lower concentration of salivary lactoferrin (p=0.011 and p=0.032), but not with age or gender.
CONCLUSIONS: In this studio, the positive PET-amyloid and periodontal disease are related independently with lower lactoferrin levels.
MATERIAL AND METHODS: Six exploratory comparison groups were designed: participants with mild cognitive impairment (n=50) (positive PET-amyloid with and without periodontal disease and negative PET-amyloid with and without periodontal disease) and cognitively normal older individuals with and without periodontal disease (n=19). All participants were recruited from referral hospitals in Granada, Spain, and from a nursing home in the same socio-economic area as the hospital participants. A salivary lactoferrin determination and a periodontal assessment has been performed in each of the participants.
RESULTS: The results show that both having an atypical ß-amyloid load in the brain (PET+) and having periodontal disease are clearly associated with a lower concentration of salivary lactoferrin (p=0.011 and p=0.032), but not with age or gender.
CONCLUSIONS: In this studio, the positive PET-amyloid and periodontal disease are related independently with lower lactoferrin levels.