International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Clinical and genomic characterization of pediatric adenovirus-associated severe acute respiratory infection: a binational study from Brazil and Colombia, 2022-2023.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Maya María Angelica, Raboni Sonia M, Giamberardino Heloisa I G, Nogueira Meri B, Giamberardino Ana Luisa G, Ferreira Laura H, Torrecilha Vivian T, Pereira Luciane A, Usuga Jaime, Aristizabal-Valencia Manuela, Vasquez Alejandro, Berg Michael G, Rebolledo Paulina A, Averhoff Francisco, Cloherty Gavin A, Hernandez-Ortiz Juan Pablo, Osorio Jorge E
Аннотация
BACKGROUND: Human adenovirus (HAdV) is detected in fewer than 10% of hospitalized children with acute respiratory infections, yet several regions reported unusual increases in 2021-2022. We investigated an HAdV outbreak detected through surveillance in Curitiba, Brazil, and Antioquia, Colombia, comparing clinical and genomic characteristics before and during the outbreak.
METHODS: We conducted a multicenter observational study of HAdV-associated severe acute respiratory infection in hospitalized children. Respiratory samples collected between February 2022 and April 2023 underwent metagenomic sequencing and hexon gene analysis. Clinical and phylogenetic analyses evaluated viral dynamics and genetic diversity.
RESULTS: A HAdV outbreak occurred in both regions during late 2022. HAdV-C predominated before the outbreak, whereas HAdV-B3 became the dominant genotype at both sites during the outbreak. During the outbreak, bronchiolitis/asthma exacerbation was most common in Antioquia, whereas pneumonia predominated in Curitiba. Phylogenetic analysis of the hexon gene identified two distinct HAdV-B3 clades that diverged from a shared ancestor but expanded independently in Brazil and Colombia.
CONCLUSION: Following relaxation of non-pharmacological measures, both regions experienced a substantial rise in HAdV-B3-associated disease. Despite increased case numbers, clinical patterns remained stable within sites but differed between regions. Integrated genomic and clinical surveillance provides important insights into adenovirus lineage expansion and outbreak dynamics.
METHODS: We conducted a multicenter observational study of HAdV-associated severe acute respiratory infection in hospitalized children. Respiratory samples collected between February 2022 and April 2023 underwent metagenomic sequencing and hexon gene analysis. Clinical and phylogenetic analyses evaluated viral dynamics and genetic diversity.
RESULTS: A HAdV outbreak occurred in both regions during late 2022. HAdV-C predominated before the outbreak, whereas HAdV-B3 became the dominant genotype at both sites during the outbreak. During the outbreak, bronchiolitis/asthma exacerbation was most common in Antioquia, whereas pneumonia predominated in Curitiba. Phylogenetic analysis of the hexon gene identified two distinct HAdV-B3 clades that diverged from a shared ancestor but expanded independently in Brazil and Colombia.
CONCLUSION: Following relaxation of non-pharmacological measures, both regions experienced a substantial rise in HAdV-B3-associated disease. Despite increased case numbers, clinical patterns remained stable within sites but differed between regions. Integrated genomic and clinical surveillance provides important insights into adenovirus lineage expansion and outbreak dynamics.