The determination of urinary 2-thio-thiazolidine-4-carboxylic-acid (TTCA) as a test for exposure to carbon disulfide.

The TTCA-test and the iodine-azide test are both useful to estimate the degree of exposure to high atmospheric concentrations of carbon disulphide. There is a relation between the increase in TTCA concentration (mmol TTCA/mol creatinine) from the begin-of-workshift urine sample to the end-of-workshift urine sample and the exposure index E of the end-of-workshift urine sample. Also, a correlation was found between the TWA-exposure (in mg CS2 per m3 of air) and the TTCA concentration (mmol TTCA/ml urine) in the urine sample at the end of the exposure period.