Modeling limbic influences on habituation deficits in chronic tinnitus aurium.

About 93% of healthy subjects suffer from tinnituslike symptoms when deprived of auditory stimuli, e.g., in a sound-proof chamber. This suggests an underlying physiological mechanism causing auditory sensations during absence of an external sound source. Grossberg suggested a mechanism by which hallucinations arise from mechanisms of learning, attention and volition. According to this mechanism notch-like hearing deficits are sufficient for experiencing auditory hallucinations, while their chronification is attributed to reorganization processes. In tinnitus sufferers the auditory sensation is accompanied by the inability to habituate to this endogenous sound. This disability might originate from a coactivation of brain areas that are only indirectly involved in cognitive processing such as areas belonging to the limbic system. Moreover subjective loudness of the tinnitus sensation is likely to depend on the amount of selective attention assigned to the tinnitus stream. Here we propose a functional model of pure-tone tinnitus in which exogenous and endogenous input into processing modules is represented as streams. We model the selection of the tinnitus stream at the subthalamic level according to its weighting. Then we propose a mechanism for the inability to habituate to this stream due to limbic coactivation and amplification by mechanisms of attentional guidance, and by the influence corticofugal projections on lower auditory processing stages. The model is able to replicate the phase stability of auditory evoked potentials as seen in tinnitus sufferers and controls.