Nature medicine · 2021
Long COVID in a prospective cohort of home-isolated patients.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Blomberg Bjørn, Mohn Kristin Greve-Isdahl, Brokstad Karl Albert, Zhou Fan, Linchausen Dagrun Waag, Hansen Bent-Are, Lartey Sarah, Onyango Therese Bredholt, Kuwelker Kanika, Sævik Marianne, Bartsch Hauke, Tøndel Camilla, Kittang Bård Reiakvam, Bergen COVID-19 Research Group, Cox Rebecca Jane, Langeland Nina
Аннотация
Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients-247 home-isolated and 65 hospitalized-comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16-30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination.