Scientific reports · 2021
Chronic liver disease not a significant comorbid condition for COVID-19.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Lin Jiahao, Bao Bingting, Khurram Nigar Anjuman, Halsey Kasey, Choi Ji Whae, Wang Lesan, Tran Thi My Linh, Liao Wei-Hua, Feldman Michael D, Zhang Paul J, Wu Jing, Bai Harrison X
Аннотация
To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes were compared between patients with and without CLD. Postmortem examination of liver in 8 critically ill COVID-19 patients was performed. There was no significant difference in the incidence of CLD between critical and non-critical groups (4.1% vs 2.9%, p = 0.259), or COVID-19 related liver injury between patients with and without CLD (65.7% vs 49.7%, p = 0.065). Postmortem examination of liver demonstrated mild liver injury associated central vein outflow obstruction and minimal to moderate portal lymphocytic infiltrate without evidence of CLD. Patients with CLD were not associated with a higher risk of liver injury or critical/fatal outcomes. CLD was not a significant comorbid condition for COVID-19.