Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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French Jacqueline A, Kanner Andres M, Bautista Jocelyn, Abou-Khalil Bassel, Browne Thomas, Harden Cynthia L, Theodore William H, Bazil Carl, Stern John, Schachter Steven C, Bergen Donna, Hirtz Deborah, Montouris Georgia D, Nespeca Mark, Gidal Barry, Marks William J, Turk William R, Fischer James H, Bourgeois Blaise, Wilner Andrew, Faught R Edward, Sachdeo Rajesh C, Beydoun Ahmad, Glauser Tracy A, American Academy of Neurology Therapeutics and Technology Assessment Subcommittee, American Academy of Neurology Quality Standards Subcommittee, American Epilepsy Society Therapeutics and Technology Assessment Subcommittee, American Epilepsy Society Quality Standards Subcommittee
Аннотация
METHODS: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Contents, and Cochrane Library for relevant articles from 1987 to March 2003.
RESULTS: All of the new AEDs were found to be appropriate for adjunctive treatment of refractory partial seizures in adults. GBP can be effective for the treatment of mixed seizure disorders, and GBP, LTG, OXC, and TPM for the treatment of refractory partial seizures in children. Limited evidence suggests that LTG and TPM also are effective for adjunctive treatment of idiopathic generalized epilepsy in adults and children, as well as treatment of the Lennox-Gastaut syndrome.
CONCLUSIONS: The choice of AED depends on seizure and/or syndrome type, patient age, concomitant medications, and AED tolerability, safety, and efficacy. The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes for which more evidence is necessary.