[Relationship between blood serum luminal and diphenylhydantoin level and the results of treatment and other clinical data in drug-resistant epilepsy].

The authors report a statistical analysis of the levels of phenobarbital (PH) and diphenylhydantoin (DPH) in a group of 100 patients with different types of epilepsy mostly resistant to pharmacological treatment. The mean values of PH and DPH were compared with the types of epilepsy, duration of the disease, additional treatment, EEG changes and therapeutic results. The following conclusions have been reached: a) therapeutic ranges of the PH and DPH levels in this group of patients were greater than those reported by others. b) no significant correlation is found between the levels of these drugs and the type of epilepsy, disease duration and EEG changes, with the exception of a positive correlation with PH level. c) Clonazepam, diazepam and mysodin raised the serum PH level in the serum, while only amizepine raised the DPH level. d) higher levels of PH and DPH were found in patients with poor therapeutic results.